I updrilled from 3/16 to 1/4 directly on a drill press.
My little drill press did not have the stroke to push all the way through so I borrowed one from a friend, it was bigger than mine but still did not reach all the way through.
I resolved the issue by inserting the drill bit initially as far as I could in the drill, install the mated spars perfectly perpendicular to the drill bit on the drill press, drill as far as I could into the blocks/spars, retract, loosen the drill bit and now move it as far out of the chuck as possible and tighten again, then drill through the last bit of material. Worked great.
Personally I'd be a little hesitant to do this by hand, I would just be too scared to stuff it up,
But, I've seen it done so I know it works, (here for example:
http://www.synelec.com.au/sonex/showcon ... ings/spars, scroll all the way to the end of the page),